Karsinoma Nasopharynx dan infeksi EBV di Indonesia; analisis aspek klinis, Patologi dan Biomolekular

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Karsinoma Nasopharynx dan infeksi EBV di Indonesia; analisis aspek klinis, Patologi dan Biomolekular
Nasopharynx Carcinoma and EBV infection in Indonesia; analysis on the Clinical, Pathology and Biomolecular aspects
JURNAL KEDOKTERAN YARSI 16 (2) : 103-112 (2008)
by
Harianto Notopuro1, Widodo A Kentjono2, Retno Handajani1, Paulus B Notopuro3
1Department of Biochemistry, School of Medicine and Tropical Disease Centre Airlangga University, Surabaya.
2Department of Ear, Nose and Throat, School of Medicine, Airlangga University and Dr Soetomo Hospital, Surabaya.
3Department of Clinical Pathology, School of Medicine, Airlangga University and Dr Soetomo Hospital, Surabaya.


ABSTRACT
Nasopharyngeal carcinoma (NPC) is a unique epithelial malignancy that occurs at a high frequency in certain regions of Southeast Asia. Previous study revealed the association between Epstein Barr Virus (EBV) and to a lesser extent, Human Papilloma Virus (HPV) with NPC. The role of the EBV in the pathogenesis of NPC was further supported by the recovery response of the tumor cells after being treated with EBV-specific T lymphocytes. The present study aims to determine the frequency distribution of EBV infection among the pathologically confirmed NPC patients and healthy control in Surabaya, Indonesia. The presence of Human Papilloma Virus infection (HPV) was also analysed.