Potensi ekstrak bawang putih (Alium sativum) sebagai analgesik dan antipiretik

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Potensi ekstrak bawang putih (Alium sativum) sebagai analgesik dan antipiretik
Potency of garlic extract (Alium sativum) as analgesic and antipyretic
JURNAL KEDOKTERAN YARSI 12 (2) : 079-084 (2004)
by
Sri Agus Sudjarwo1, Wisnu Setyari 1, Koerniasari 2
1Department of Pharmacology, Airlangga University, School of Medicine, Surabaya
2Academy of Environment Health, Surabaya


ABSTRACT
This study was conducted to prove whether garlic extract has analgesic and antipyretic effect. Analgesic test used 24 mice were divided into control group (6 mice were given aquadest) and treatment group (each dose consisted of 6 mice were given garlic extract at 0.005 ml/gr BW, 0.01 ml/gr BW and 0.02 ml/gr BW). The mice is placed on a hot plate, the observed responses are agitation, rapid withdrawal of the paws, licking of the fore paws and or hinds paws and jumping. The results showed that garlic extract 0.01 ml/gr BW and 0.02 ml/gr BW but not 0.005 ml/gr BW significantly inhibited pain respons in mice induced by hot plate. While antipyretic test used 30 rats were divided into negative control group (6 rats were given aquadest), positive control group (6 rats were injected with Sacharomyces cereviciae 25% and treatment group (each dose consisted of 6 rats were injected with Sacharomyces cereviciae 25% and given garlic extract at 0.005 ml/gr BW, 0.01 ml/gr BW and 0.02 ml/gr BW). The results showed that Sacharomyces cereviciae 25 % increased body temperature of rats which was significantly inhibited by garlic extract at 0.01 ml/gr BW and 0.02 ml/grBW but not 0.005 ml/gr BW. From the results suggest that garlic extract has analgesic and antipyretic effect which dose dependent manner