Jurnal Kedokteran YARSI
Aktivitas antibakteri ekstrak daun Eclipta alba L. Hassk serta ekstrak dan minyak atsiri daun Piper betle L. terhadap bakteri penyebab karies gigi

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Aktivitas antibakteri ekstrak daun Eclipta alba L. Hassk serta ekstrak dan minyak atsiri daun Piper betle L. terhadap bakteri penyebab karies gigi
Antibacterial activity of the extract of Eclipta alba L. Hassk leaves and the extract and volatile oil of Piper betle L. leaves on bacteria as the causative agents of dental caries
JURNAL KEDOKTERAN YARSI 13 (3) : 281-287 (2005)
by
Kartini Hasballah 1, Murniana 2, Al Azhar3
1Department of Pharmacology, Syiah Kuala University Faculty of Medicine, Banda Aceh
2Department of Chemistry, Syiah Kuala University Faculty of Mathematic and Natural Sciences, Banda Aceh
3Department of Biochemistry, Syiah Kuala University Faculty of Medicine Veterinary, Banda Aceh


ABSTRACT
The bioassay of ethanol, chloroform, ethyl acetate and butanol extracts of Eclipta alba L. and Piper betle L. leaves along with volatile oil of P. betle L. have been done using Streptococcus mutans, Lactobacillus kaesal and Actinomyces viscosus as test bacteria. E. alba and P. betle leaves were separately extracted by soxhletation method in 96 % ethanol followed by partition step with chloroform, ethyl acetate and butanol respectively. Volatile oil from P. betle was obtained by distillation. All extracts and volatile oil were diluted into concentrations of 0,5%,1%, 5%, 10%, 15%, and 20% w/v successively. Inhibitory effects of the extracts on the tested bacteria were determined applying the agar dilution method. The results showed that (1) ethanol and ethyl acetate extracts of E. alba leaves had an inhibitory effect on the growth of three causative bacteria of dental caries i.e. S. mutans, L. kaesal and A. viscosus. Chloroform extract of E. alba leaves was only active on A. viscosus,and its butanol extract was inactive to A. viscosus; (2) all ethanol, ethyl acetate, chloroform and butanol extracts of P. betle leaves as well as its volatile oil showed an antibacterial activity on S. mutans, L. kaesal and A. viscosus; (3) ethanol extract of P. betle showed the highest antibacterial activity; (4) phytochemistry assay showed that extracts of E. alba and P. betle leaves contained some secondary metabolites identified as alkaloid, phenolic, flavonoid, steroid or saponine compounds. Volatile oil of P. betle leaves contained only one secondary metabolite characterized as a terpenoid.
 
Efikasi insektisida actelic 50 EC dengan aplikasi thermal fogging terhadap nyamuk Aedes aegypti vektor demam berdarah dengue

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Efikasi insektisida actelic 50 EC dengan aplikasi thermal fogging terhadap nyamuk Aedes aegypti vektor demam berdarah dengue
The efficacy of actelic 50 EC insecticide against dengue haemorrhagic fiver vector Aedes aegypti by thermal fogging application
JURNAL KEDOKTERAN YARSI 13 (3) : 288-292 (2005)
by
Akhid Darwin, Damar Tri Boewono dan Hasan Boesri
Vector and Disease Reservoir Control Research Unit, National Institute of Health Research and Development, Departement of Health of the Republic of Indonesia, Salatiga


ABSTRACT
The invention of an alternative insecticide with the aim to control Aedes aegypti is important in order to subtitute an insecticide which provide a resistance effect to the vector. A trial on Actelic 50 EC at dosages of respectively 50 ml/Ha, 75 ml/Ha, 100 ml/Ha, 150 ml/Ha dan 200 ml/Ha by applying the thermal fogging technique against the Dengue Haemorrhagic Fever vector Aedes aegypti has been carried out. The fogging was conducted in the morning at the residence of the people living in Salatiga in the year 2005. The bioassay showed that as many as 100% of mortality of mosquitoes in the house was obtained by using Actelic 50 EC at dosages of 100 ml/Ha, 150 ml/Ha and 200 ml/Ha applying the thermal fogging (ULV) technique whereas outside of the house it was also effective at dosages of 150 ml/Ha and 200 ml/Ha. Indoor and outdoor fogging gave a different effect to kill Aedes aegypti mosquitoes.
 
Hubungan antara beberapa ukuran antropometri ekstremitas atas dan kemampuan memukul yang dinilai dengan Poole Forehand Clear Test (penelitian pada atlet Bulutangkis PB Djarum Kudus)

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Hubungan antara beberapa ukuran antropometri ekstremitas atas dan kemampuan memukul yang dinilai dengan Poole Forehand Clear Test (penelitian pada atlet Bulutangkis PB Djarum Kudus)
Correlation between anthropometric measurements of upper extremity and stroke capability using poole forehand clear test (Study on badminton athletes of PB Djarum Kudus)
JURNAL KEDOKTERAN YARSI 13 (3) : 293-297 (2005)
by
Hardhono Susanto
Department of Anatomy, DIPONEGORO UNIVERSITY School of Medicine Semarang


ABSTRACT
Stroke skill in badminton contains strength and speed elements that become one of many important factors for winning the game. Whereas anthropometric measurements can be used to predict any functional abilities. The aim of this study is to find out the correlation among some anthropometric measurements in upper extremity (i.e. arm length, forearm length, arm circumference, forearm circumference) and stroke skill evaluated by used Poole Forehand Clear Test. The subjects of this cross sectional study consist of 27 badminton athletes from PB Djarum Kudus (16 males and 11 females) aged 14-20 years old. As the result, there is a significant correlation between the score of Poole Forehand Clear Test for stroke skill and arm circumference (p=0.036) and forearm length (p=0.003). Both of these anthropometric measurements are strong predictors for stroke skill in male athletes. However, all the evaluated anthropometric measurements of female athletes are not significant correlation (p>0.05) with Poole Forehand Clear Test.
 
A rapid isocratic HPLC assay of diminazene aceturate in blood plasma

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A rapid isocratic HPLC assay of diminazene aceturate in blood plasma
JURNAL KEDOKTERAN YARSI 13 (3) : 298-305 (2005)
by
Mochamad Lazuardi
Research staff on Medical-Pharmacy Depth., Medical Faculty Airlangga University, Surabaya


ABSTRACT
A spesific and sensitive method has been developed for the separation and quantification of diminazene aceturate in goats plasma. Diminazen in the plasma samples were obtained by solid phase extraction 3 ml (ODS C-18) after the addition of 0.025 M ion-pairing reagent (1-octanosulphonic acid) in acetonitrile HPLC grade: aqua pro injecton 90% : 10%, and glacial acetic acid 2% (pH 3,8). Reverse-phase ion pairing HPLC system with 0.005 M 1-octanosulphonic acid (mobile phase) were used for the analysis. There was 85 – 88% extraction efficiency after 5 replicates extracts of each samples. The limit of detection was 1.1 ?g/ml and limit of quantification was 3.2 ?g/ml at a detection wavelength of 370 nm,
 
Benda asing esofagus pada anak di RSU Dr. Soetomo Surabaya

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Benda asing esofagus pada anak di RSU Dr. Soetomo Surabaya
Pediatric esophageal foreign bodies in Dr. Soetomo Hospital Surabaya
JURNAL KEDOKTERAN YARSI 13 (3) : 306-312 (2005)
by
Sri Herawati Juniati
Department of Otorhinolaryngology Airlangga University School of Medicine Dr. Soetomo Hospita Surabaya


ABSTRACT
Foreign body impaction is a common clinical finding, but sometime could become a serious problem. Some of the foreign material or objects will pass harmlessly through the gastrointestinal tract. Impaction will occur in the esophagus either due to the size or nature of the material or the narrowing of the esophagus. The aim of this study is to describe the esophageal foreign bodies in pediatric patients during 5 years (2000-2004) in ENT Department Dr. Soetomo Hospital Surabaya. A total of 171 consecutive pediatric patients presenting with history of foreign body ingestion were included. A structured questionnaire was designed to record information of all the patients such as age, gender, kinds of foreign bodies, procedures and complications. The result of this study showed that the youngest patient was 15-days-old with gold earring and the oldest was 15-years-old with tooth impaction. Children up to the age of 5-years-old was 63.74%, males were 53.22% and female were 46.78%. The cervical esophagus was the commonest site for impaction. The rigid esophagoscopy was the only procedure in this study. Extraction of the foreign bodies were successful in all patients (100%). Coins were the commonest foreign body. Complications occurred in 5.85% of the patient; death occurred in 1 patient due to the bleeding after the patient was discharged on request.
 
Hubungan polimorfisme Pro12Ala gen PPAR?2 terhadap obesitas dan diabetes mellitus tipe 2 (DMT2)

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Hubungan polimorfisme Pro12Ala gen PPAR?2 terhadap obesitas dan diabetes mellitus tipe 2 (DMT2)
Association of the Pro12Ala polymorphism of PPAR ?2 gene to obesity and type 2 diabetes mellitus (T2DM)
JURNAL KEDOKTERAN YARSI 13 (3) : 313-322 (2005)
by
T. Susmiarsih
Departement of Biology, YARSI UNIVERSITY School of Medicine, Jakarta


ABSTRACT
Obesity and Type 2 Diabetes Mellitus (T2DM) have become a worldwide public health problem. The improvement of health, socio-economic status and alteration in lifestyle (more westernized tend to) increase the incidence or prevalence of obesity and T2DM. Obesity is a symptom or disorder determined by the interaction of several environmental and genetic factors. It is a result of imbalance between energy intake and expenditure. T2DM is a reflection of an abnormality in insulin production by pancreatic ß cells or/and in the ability of target tissues to respond to insulin. It has been reported that some genetic variations, known as single nucleotide polymorphisms (SNPs) may influence the susceptibility to obesity and T2DM, such as C896G (Pro12Ala) of PPAR ?2 gene. However, some studies reported that this polymorphism was not involved in the pathogenesis of obesity and T2DM. Hence, the role of Pro12Ala of PPAR ?2 gene remains controversy in various populations. The aims of this study was to elucidate the association of Pro12Ala of PPAR ?2 gene to obesity and T2DM in Indonesian population. PPAR ?2 is a nuclear hormone receptor which plays a central role in the control of adipocyte gene expression that involves in thermogenesis, lipid metabolism and glucose homeostatic process. To study the association of the polymorphism of Pro12Ala of PPAR ?2 gene to obesity and T2DM, some 100 obese with T2DM individuals and 90 normal individuals were examined employing by PCR-RFLP. Restriction endonucleases employed was BstUI. The results of the study revealed that the allele frequencies of Ala12 was 0,025 in obese with T2DM individuals and C896G (Pro12Ala) of PPAR ?2 gene was associated with decrease of the blood glucose levels (p=0,025) in obese with T2DM individuals. It was concluded that Pro12Ala of PPAR ?2 gene might play a role as a predisposing factor for obesity and T2DM. Further studies are still required to confirm this finding.
 
Patofisiologi molekuler pada stroke

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Patofisiologi molekuler pada stroke
Molecular pathophysiology in stroke
JURNAL KEDOKTERAN YARSI 13 (3) : 323-328 (2005)
by
Hasyim Fachir
Department of Neurology, Ulin General Hospital/Lambung Mangkurat University School of Medicine, Banjarmasin-South Kalimantan


ABSTRACT
Stroke is one of cerebrovascular disorders that causes serious problem in the world until now. These problems include disability, morbidity caused by stroke complication and death. Development of molecular biology increases knowledge about cerebral blood flow, role of calcium and free radical towards neuron damage. Regulation of cerebral blood flow in the time proportion is related to the pathologic process and the mechanism of adaptation. Calcium influx induces some processes that increases susceptibility to neuronal death. Oxidative stress in ischemic stroke is due to the ischemic reperfusion injury, glutamate excitotoxicity, acidosis and inflammation. This knowledge is beneficial to increase quality in stroke management.
 
Prospek hormon Testosteron Undekanoat (TU) sendiri dan kombinasinya untuk kontrasepsi pria.

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Prospek hormon Testosteron Undekanoat (TU) sendiri dan kombinasinya untuk kontrasepsi pria.
[Suatu upaya dalam pengembangan kontrasepsi hormonal pada pria Indonesia]
Prospect of using isolated Testosterone Undekanoat (TU) and its combination in male contraception.
[An effort in producing hormonal contraception for Indonesian male]
JURNAL KEDOKTERAN YARSI 13 (3) : 329-337 (2005)
by
Syafruddin Ilyas
North Sumatera University School of Mathematics and Natural Sciences, Medan


ABSTRACT
Male contraception deserves special attention from both government and academic circle that leads to its practical application. This is due to limination of methods and means that discourages male to be actively participanting in family planning. TU is one of prospective male contraception after TE has been discarded. TU has longs pharmaceological effect compared to TE and TU is much safes although it is still in on going research work. TU came out to make volunteer to have severe oligospemia to azoospermia and this effect is reversible. The use of TU has been developed in combination with other progesterone such as DMPA, LNG, CPA, and NET-EN. The combination is more effective compared to the isolated TU. Further research is needed before it can be approved for public use.
 
Osteoporosis in men: a natural phenomenon

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Osteoporosis in men: a natural phenomenon
JURNAL KEDOKTERAN YARSI 13 (3) : 338-342 (2005)
by
Yuni Ahda
Department of Biology, Faculty of Mathematic and Sciences, State University of Padang


ABSTRACT
Osteoporosis in men has become an important problem in public health. Both men and women ageing is accompanied by continuous bone loss and by an exponential increase in the incidence of osteoporotic fracture, with a female to male incidence ratio of about 2 to 3 in the elderly for hip and vertebral fractures. Morbidity after osteoporotic fractures appears to be more serious and mortality more common in men than in women. It is apparent that notwithstanding the existing sex differences in pathophysiology of osteoporosis and the difference in age-specific incidence of osteoporotic fractures, there are also important similarities between osteoporosis in women and men. The higher incidence of fracture in women than in men results from quantitative differences in risk factors rather than from different risk factors. Even though there are sex differences in bone geometry, incidence of fracture seems to be similar in men and women for a same absolute areal bone mineral density.
 
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