Jurnal Kedokteran YARSI
Prevalensi Bayi Lahir Cacat (Malformasi Kongenital) di Rumah Sakit Pendidikan Fakultas Kedokteran Universitas YARSI

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Oleh Administrator   
Senin, 24 September 2012 11:28

Prevalensi Bayi Lahir Cacat (Malformasi Kongenital) di Rumah Sakit Pendidikan Fakultas Kedokteran Universitas YARSI

The Prevalence of Congenital Malformations in the Teaching Hospitals, Faculty of Medicine YARSI University

JURNAL KEDOKTERAN YARSI 17 (2) : 101-110 (2009)
by
Samsul Mustofa1, T. Susmiarsih1, Riyani Wikaningrum2
1Department of Biology, Faculty of Medicine, YARSI University, Jakarta
2Department of Microbiology, Faculty of Medicine, YARSI University, Jakarta

KEYWORDS
congenital malformation; morbidity; medical record; pregnancy

ABSTRACT
Congenital Malformations was instrumental in perinatal morbidity and infant mortality. Patients with severe disorders are classified to be affected physically, mentally, and socially and require special attention. Prevalence data from various types of congenital malformations may be useful to plan primary prevention measures for such disorders. The purpose of this study was to examine the prevalence of congenital malformations at the teaching hospitals, Faculty of Medicine, YARSI University. In this study, data were obtained from medical records in four teaching hospitals i.e. Abdul Muluk Hospital in Bandar Lampung, Lampung, Serang General Hospital in Serang, Banten, Garut General Hospital in Garut, and Gunung Jati General Hospital in Cirebon, West Java, within a period of three years i.e. 2005 to 2007. Based on ICD-10 codes, eight groups involving 18 types of birth defects were recorded. Among 25,276 babies born in four previously mentioned hospitals, 283 babies were born with congenital malformation. The prevalence of congenital malformations in Abdul Muluk Hospital was 11.31% with the frequency of 5.961/1,000 live birth, Serang Hospital was 13.78% with the frequency of 7.163/1,000 live birth, Garut Hospital was 33.92% with the frequency of 9.777/1,000 live birth and Gunung Jati Hospital was 40.99% with the frequency of 24.98/1000 live birth. Various disorders were noted, being the most common was disorder in the digestive system (25.80%), followed by the musculoskeletal system (20.49%), and the nervous system (16.61%). In conclusion, the total prevalence of congenital malformations in the teaching hospital, Faculty of Medicine, YARSI University was 1.12% with the frequency of 11.2/1000 live births. Congenital malformations were particularly prominent in Gunung Jati General Hospitals Cirebon, West Java.

 
Efek Pentagamavunon-0 terhadap Konsentrasi cAMP dan Progesteron pada Kultur Sel Luteal yang Mengandung Teofilin

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Oleh Administrator   
Senin, 24 September 2012 11:09

Efek Pentagamavunon-0 terhadap Konsentrasi cAMP dan Progesteron pada Kultur Sel Luteal yang Mengandung Teofilin
The Effect of Pentagamavunon-0 on cAMP and Progesteron Concentrations of Luteal Cells Culture Containing Theophylline

JURNAL KEDOKTERAN YARSI 17 (2) : 093-100 (2009)
by
Endang Purwaningsih1, Sri Kadarsih Soejono2, Djaswadi Dasuki3, Edy Meiyanto4
1Department of Anatomy (Biology), Faculty of Madicine, YARSI University, Jakarta
2Department of Physiology, Faculty of Medicine, Gadjah Mada University, Yogyakarta
3Department of Obstetric and Gynecology, Faculty of Madicine, Gadjah Mada University, Yogyakarta
4Department of Molecular Biology, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta

KEYWORDS
signal transduction; curcumin analog; culture plate; ELISA; RIA

ABSTRACT
Curcumin analog (Pentagamavunon-0/PGV-0) can inhibit steroidogenesis of luteal cell culture. Corpus luteum secretes progesterone by LH stimulation. The main transduction signal of luteal cells steroidogenesis is through the cAMP/PKA. The objective of this study was to know the effect of PGV-0 on cAMP and progesterone concentration of luteal cell culture containing theophylline. The subject was corpus luteum of rat Sprague Dawley strain induced with PMSG (10 IU). PGV-0 was given shortly after the stimulation of LH and or PGF2α with or without theophyline. The cell culture then put into the incubator for 24 hours. Concentration of cAMP was assessed by ELISA whereas the progesterone concentration was determined by RIA. The result showed that LH stimulation caused cAMP and progesterone increase significantly. The inhibition of PGF2α on cAMP and progesterone concentrations showed no significant difference compared to the control. Theophylline increased the cAMP and progesterone concentration significantly but not to LH stimulation. PGV-0 did not inhibit cAMP concentration but PGV-0 inhibited the progesterone concentration by LH stimulation. In conclusion, PGV-0 inhibits signal transduction of lutheal cell in down stream cAMP.

 
Antioxidant Activity and Anticarcinogenic Properties of “Sisik Naga”(Drymoglossum piloselloides Presl.)

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Oleh Administrator   
Senin, 24 September 2012 10:58

Antioxidant Activity and Anticarcinogenic Properties of “Sisik Naga”(Drymoglossum piloselloides Presl.)

JURNAL KEDOKTERAN YARSI 17 (2) : 089-092 (2009)
by
Susi Endrini
Department of Biochemistry, Faculty of Medicine YARSI University, Jakarta

KEYWORDS
MTT assay; “sisik naga”; MCF-7; Antioxidant activity; cytotoxic properties

ABSTRACT
The research was conducted to determine the anticarcinogenic properties of “sisik naga”(Drymoglossum piloselloides Presl.), by the microculture tetrazolium salt (MTT) assay on the human breast carcinoma dependent-hormone (MCF-7) cell lines. The preliminary results showed that the “sisik naga” extract displayed the cytotoxic effects against MCF-7 with IC50-value of 83.63μg/ml. The antioxidative activity of the extracts which could contribute to their cytotoxic properties was also studied. The “sisik naga” extract was found to have high antioxidant activity with IC50-value of 4.229 ppm. The strong cytotoxic properties of the “sisik naga” extract could be due to its high antioxidant activity.

 
APRI index changes after 4 weeks treatment of Pentoxifylline in Chronic Hepatitis B

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JURNAL KEDOKTERAN YARSI 16 (2) : 083-086 (2008)
by
Zulfan1, Lukman Hakim Zain2
1Department of Internal Medicine, YARSI University School of Medicine, Jakarta
2Gastroentero-Hepatology Division, Department of Internal Medicine USU Medical School /Adam Malik Hospital Medan
ABSTRACT
Nowadays studies have shown that liver fibrosis is a reversible process. Theraupetic target on hepatic stellate cell (HSC) through inhibition of fibrotic signaling transduction is one of the way to treat liver fibrosis (e.g. pentoxifylline). APRI index, one of the indirect marker of liver fibrosis, had shown significant correlation (Spearman correlation  = 0.7) with liver fibrosis degree in hepatitis B and C. This study was aimed to evaluate the effect of pentoxifylline treatment in 4 weeks for liver fibrosis measured by APRI index. We conducted clinical trial on eleven chronic hepatitis B patients from Adam Malik Hospital Medan, with positive HBsAg at least 6 months after follow up. They were treated with pentoxifylline for 4 weeks. Before and after treatment, APRI index was measured. The result showed a decrease of ALT (64.64±49.61 vs 50.64±26.13; p=0.28), but AST and APRI index increased (91.82± 100.16 vs 97.91±146.75; p=0.79) and (1.17±1.07 vs 1.31±1.84; p=0.96) respectively. It was concluded that the effect of pentoxifylline as antifibrotic in the liver measured by APRI index was not proven. It was shown that APRI index increased after 4 weeks treatment of pentoxifylline.
 
Populasi bakteri pada Feses Neonatus: Penelitian pendahuluan

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Populasi bakteri pada Feses Neonatus: Penelitian pendahuluan
Bacterial Populations in Neonatal Feces: A Preliminary study
JURNAL KEDOKTERAN YARSI 16 (2) : 087-090 (2008)
by
Riyani Wikaningrum, Jekti T. Rochani, Titiek Djannatun, Dian Widiyanti, Abdul Rahim Pane*)
Department of Microbiology, YARSI UNIVERSITY School of Medicine, Jakarta
*)Late author


ABSTRACT
Recent published data have outlined a relationship between the composition of the intestinal microflora and allergic inflammation, autoimmunity, chronic bowel inflammation, psychiatric, cognitive and behavioral disturbances. Factors influencing intestinal microflora are environment, genetic predisposition, diet, age, diseases, drugs, stressor. This preliminary study is to establish local reference of microbial flora in neonates. This study included samples taken from 20 neonates, age 1 – 7 days, from a private hospital in Jakarta. All samples were sent to microbiology laboratory without transport media and processed immediately. Bacteriological cultures for aerob and anaerob bacteria were performed according to the standard methods. Aerob and anaerob bacterial species were isolated from all samples, ranged 2 – 5 species per sample. Enterobacteriaceae were found to be dominant isolates (25% - 75%); followed by Streptococcus anhaemolyticus (60%), Staphylococcus epidermidis (40%), Staphylococcus aureus (5%), Clostridium difficile (5%), Bacteroides fragilis (5%), Bifidobacterium sp. (10%), Lactobacillus sp. (5%) and yeast (5%). These data indicated that aerob and facultative anaerob bacteria were predominant in neonates. However Bifidobacterium, Lactobacillus and Clostridium difficile could be found. Further studies are needed to confirm this finding using larger number of samples and involving various age group.
 
Body mass index and predicted percent body fat of Yogyakarta and Flores Pygmy populations

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JURNAL KEDOKTERAN YARSI (16 (2) : 073-082 (2008)
by
Janatin Hastuti, Neni T Rahmawati, Rusyad A Suriyanto, Koeshardjono*), T Jacob*)
Laboratory of Bioanthropology and Phalaeoanthropology, Faculty of Medicine Gadjah Mada University Yogyakarta
*)Late author
ABSTRACT
Body mass index and percent body fat are two parameters used to assess human body composition, which has several advantages for clinical practice, sport, growth, and normal population as well. There are many populations distributed in the wide Indonesian area that have various geographical characteristics. As evidence, plateau environments are inhabited by many populations whose physical and physiological traits are vary. This study was aimed to investigate body mass index (BMI) and predicted percent body fat (%BF) between Yogyakarta populations and Flores pygmy population in East Nusa Tenggara Province residing on a similar plateau environment. The present study was done on 105 people (51 males and 54 females) of Samigaluh Kulon Progo (Yogyakarta), 87 people (40 males and 47 females) of Gunung Kidul (Yogyakarta) and 75 pygmy people of Manggarai, Flores (East Nusa Tenggara). Height and weight were measured in all participants of this study. BMI was calculated from height and weight measurements and %BF was predicted based on BMI value using formula of Guricci et al (1998). Then, t-student test, linear regression, and chi square test were performed to analyze the data. The results indicated that Samigaluh and Gunung Kidul populations in Yogyakarta have considerably greater average of height and weight compare to Flores Pygmy population. However, differences in BMI and %BF were only significant between Flores Pygmy and Yogyakarta males population. Despite majority of both populations being under normal category, nutritional category based on BMI showed significant difference between Flores Pygmy and Yogyakarta population. In addition, more underweight individuals were also observed in Flores Pygmy. In conclusion, Yogyakarta population was considerably taller and heavier than Flores Pygmy population, however, in terms of %BF and BMI, they were nearly the same lean and body constitution. It is suggested that lower BMI and %BF represented by small body constitution and leanness in populations living on plateau in Yogyakarta and Flores are likely due to significant adaptation to their environment.
 
Pemanfaatan darah manusia yang kadaluarsa sebagai pengganti darah domba dalam pembuatan media Agar Darah Plat (ADP)

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Pemanfaatan darah manusia yang kadaluarsa sebagai pengganti darah domba dalam pembuatan media Agar Darah Plat (ADP)
The use of expired human blood as substitution of the sheep blood in preparation of Blood Agar Media (BAM)
JURNAL KEDOKTERAN YARSI 16 (2) : 091-097 (2008)
by
Titiek Djannatun, Jekti T. Rochani, Riyani Wikaningrum, Dian Widiyanti, Abdul Rahim Pane*)
Department of Microbiology YARSI UNIVERSITY School of Medicine, Jakarta
*)Late author


ABSTRACT
The use of blood agar media to grow and to isolate the pathogenic bacteria, and to compare the hemolytic ability of the bacteria is well known. The aim of this study was to investigate the possibility of using expired human blood as substitute for the sheep blood agar media. In this study five days before expired and five days after expired human blood were washed once, twice and centrifuged. Sheep blood was used as positive control and five days after and before expired blood without treatment was used as negative control. The prepared media were used to grow six isolates wild strain bacteria (Staphylococcus aureus, Streptococcus ? haemolyticus, Streptococcus ? haemolyticus, Streptococcus pneumoniae, Vibrio El Tor and Clostridium perfringens). The result indicated that blood agar medium, prepared using human blood which was nearly expired or expired, have the same results in culture growth of the tested bacteria compared to the standard blood agar had media using sheep blood.
 
Efektifitas pemakaian ulang ginjal buatan

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Efektifitas pemakaian ulang ginjal buatan
The effectiveness of dialyzer reuse
JURNAL KEDOKTERAN YARSI 16 (2) : 098-102 (2008)
by
Linda Armelia
Department of Internal Medicine, YARSI UNIVERSITY School of Medicine, Jakarta


ABSTRACT
Hemodialysis is a therapy for patient with end state renal diseases, but it is very expensive specially dialyzer. Now we could use a reuse of dialyzer to reduce the cost. The aim of this study was to examine the effectiveness of dialyzer reuse and its frequent possible reuse. A prospective study with the comparative experimental approach was carried out. The population was all patient with end state renal diseases underwent twice hemodialysis in a week at fifth hours in each period at least within three months using acetate dialysate and reuse dialyzer in the Dialysis Unit. Sample size was 20 subjects determined based on time continuum It was concluded that the reuse dialyzer could be used 6,06 ? 2,01 times without negative influence on dialysis adecuacy.
 
Karsinoma Nasopharynx dan infeksi EBV di Indonesia; analisis aspek klinis, Patologi dan Biomolekular

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Karsinoma Nasopharynx dan infeksi EBV di Indonesia; analisis aspek klinis, Patologi dan Biomolekular
Nasopharynx Carcinoma and EBV infection in Indonesia; analysis on the Clinical, Pathology and Biomolecular aspects
JURNAL KEDOKTERAN YARSI 16 (2) : 103-112 (2008)
by
Harianto Notopuro1, Widodo A Kentjono2, Retno Handajani1, Paulus B Notopuro3
1Department of Biochemistry, School of Medicine and Tropical Disease Centre Airlangga University, Surabaya.
2Department of Ear, Nose and Throat, School of Medicine, Airlangga University and Dr Soetomo Hospital, Surabaya.
3Department of Clinical Pathology, School of Medicine, Airlangga University and Dr Soetomo Hospital, Surabaya.


ABSTRACT
Nasopharyngeal carcinoma (NPC) is a unique epithelial malignancy that occurs at a high frequency in certain regions of Southeast Asia. Previous study revealed the association between Epstein Barr Virus (EBV) and to a lesser extent, Human Papilloma Virus (HPV) with NPC. The role of the EBV in the pathogenesis of NPC was further supported by the recovery response of the tumor cells after being treated with EBV-specific T lymphocytes. The present study aims to determine the frequency distribution of EBV infection among the pathologically confirmed NPC patients and healthy control in Surabaya, Indonesia. The presence of Human Papilloma Virus infection (HPV) was also analysed.
 
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